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Xenohormetic, hormetic and cytostatic selective forces driving longevity at the ecosystemic level

Alexander A. Goldberg, Pavlo Kyryakov, Simon D. Bourque, Vladimir I. Titorenko

Aging · 2010 · ▲ 22 citations

Loss of proteostasis Yeast

Abstract

We recently found that lithocholic acid (LCA), a bile acid, extends yeast longevity. Unlike mammals, yeast do not synthesize bile acids. We therefore propose that bile acids released into the environment by mammals may act as interspecies chemical signals providing longevity benefits to yeast and, perhaps, other species within an ecosystem.

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Provenance

Source: OpenAlex
DOI: 10.18632/aging.100186
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Fetched: 2026-06-18 MST

Cite this

APA

Goldberg, A.A., Kyryakov, P., Bourque, S.D., & Titorenko, V.I. (2010). Xenohormetic, hormetic and cytostatic selective forces driving longevity at the ecosystemic level. <em>Aging</em>. https://doi.org/10.18632/aging.100186

Vancouver

Goldberg AA, Kyryakov P, Bourque SD, Titorenko VI. Xenohormetic, hormetic and cytostatic selective forces driving longevity at the ecosystemic level. Aging. 2010. doi:10.18632/aging.100186.

BibTeX

@article{alexander2010Xenoho, title = {Xenohormetic, hormetic and cytostatic selective forces driving longevity at the ecosystemic level}, author = {Alexander A. Goldberg and Pavlo Kyryakov and Simon D. Bourque and Vladimir I. Titorenko}, journal = {Aging}, year = {2010}, doi = {10.18632/aging.100186}, }