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Transformation of the proteasome with age‐related macular degeneration

Cheryl M. Ethen, Stacy A. Hussong, Cavan Reilly, Xiao Feng, Timothy W. Olsen, Deborah A. Ferrington

FEBS Letters · 2007 · ▲ 77 citations

Chronic inflammation Human

Abstract

The proteasome mediates pathways associated with oxidative stress and inflammation, two pathogenic events correlated with age-related macular degeneration (AMD). In human donor eyes corresponding to four stages of AMD, we found the proteasomal chymotrypsin-like activity increased in neurosensory retina with disease progression. Increased activity correlated with a dramatic increase in the inducible subunits of the immunoproteasome, which was not due to an increase in CD45 positive immune cells in the retina. The novel observation of proteasome transformation may reflect retinal response to local inflammation or oxidative stress with AMD.

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Provenance

Source: OpenAlex
DOI: 10.1016/j.febslet.2007.01.061
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Fetched: 2026-10-19 MST

Cite this

APA

Ethen, C.M., Hussong, S.A., Reilly, C., Feng, X., Olsen, T.W., & Ferrington, D.A. (2007). Transformation of the proteasome with age‐related macular degeneration. <em>FEBS Letters</em>. https://doi.org/10.1016/j.febslet.2007.01.061

Vancouver

Ethen CM, Hussong SA, Reilly C, Feng X, Olsen TW, Ferrington DA. Transformation of the proteasome with age‐related macular degeneration. FEBS Letters. 2007. doi:10.1016/j.febslet.2007.01.061.

BibTeX

@article{cheryl2007Transf, title = {Transformation of the proteasome with age‐related macular degeneration}, author = {Cheryl M. Ethen and Stacy A. Hussong and Cavan Reilly and Xiao Feng and Timothy W. Olsen and Deborah A. Ferrington}, journal = {FEBS Letters}, year = {2007}, doi = {10.1016/j.febslet.2007.01.061}, }