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Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis

Olivier Govaere, Simon Cockell, DINA G. TINIAKOS, Rachel A. Queen, Ramy Younes, Michèle Vacca, Leigh E. Alexander, Federico Ravaioli, Jeremy M. Palmer, Salvatore Petta, Jérôme Boursier, Chiara Rosso, Katherine Johnson, Kristy Wonders, Christopher Paul Day

Science Translational Medicine · 2020 · ▲ 472 citations

Abstract

, whereas GDF15 supplementation tempered the inflammatory response in macrophages upon lipid loading and lipopolysaccharide stimulation. This study provides insights into the pathophysiology of progressive fibrosing steatohepatitis, and proof of principle that transcriptomic changes represent potentially tractable and clinically relevant markers of disease progression.

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Provenance

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OpenAlex
DOI
10.1126/scitranslmed.aba4448
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2026-10-15 MST

Cite this

APA
Govaere, O., Cockell, S., TINIAKOS, D.G., Queen, R.A., Younes, R., Vacca, M., Alexander, L.E., Ravaioli, F., Palmer, J.M., Petta, S., Boursier, J., Rosso, C., Johnson, K., Wonders, K., Day, C.P., Ekstedt, M., Orešič, M., Darlay, R., Cordell, H.J., &amp; Marra, F. (2020). Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis. <em>Science Translational Medicine</em>. https://doi.org/10.1126/scitranslmed.aba4448
Vancouver
Govaere O, Cockell S, TINIAKOS DG, Queen RA, Younes R, Vacca M, et al. Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis. Science Translational Medicine. 2020. doi:10.1126/scitranslmed.aba4448.
BibTeX
@unpublished{olivier2020Transc, title = {Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis}, author = {Olivier Govaere and Simon Cockell and DINA G. TINIAKOS and Rachel A. Queen and Ramy Younes and Michèle Vacca and Leigh E. Alexander and Federico Ravaioli and Jeremy M. Palmer and Salvatore Petta and Jérôme Boursier and Chiara Rosso and Katherine Johnson and Kristy Wonders and Christopher Paul Day and Mattias Ekstedt and Matej Orešič and Rebecca Darlay and Heather Jane Cordell and Fabio Marra and Antonio Vidal‐Puig and Pierre Bédossa and Jörn Markus Schattenberg and Karine Clément and Michael Allison}, journal = {Science Translational Medicine}, year = {2020}, doi = {10.1126/scitranslmed.aba4448}, }

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