Therapeutic Targeting of the SIRT1-SREBP Pathway in Metabolic Disorders

The enzymes known as sirtuins, or silent information regulator 2, are histone deacetylases that depend on nicotinamide adenine dinucleotide (NAD+). In addition to its well-established role in prolonging longevity, further study is necessary to examine the beneficial effects of Sirtuin 1 (SIRT1), a member of the sirtuin group, on lipid metabolism. SIRT1 has been extensively associated with the control of gene expression. The SIRT1 substrate sterol regulatory element-binding protein (SREBP) has garnered a lot of attention because of its involvement in a number of biological processes, such as metabolic activities, DNA damage repair, and cell cycle control. Therefore, the aim of this investigation was to examine and clarify the relationship between SIRT1 and SREBPs and evaluate the role of SIRT1/SREBPs in reducing dysfunction in lipid metabolism. Investigating whether SIRT1 and SREBPs may be used as feasible targets for therapeutic intervention in the management of diabetic complications was the aim of this study.