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The Roles of Sirtuin Family Proteins in Cancer Progression

Erhu Zhao, Jianbing Hou, Xiaoxue Ke, Muhammad Nadeem Abbas, Saima Kausar, Lei Zhang, Hongjuan Cui

Cancers · 2019 · ▲ 122 citations

Deregulated nutrient-sensing Review

Abstract

Sirtuin family members are characterized by either mono-ADP-ribosyltransferase or deacylase activity and are linked to various cancer-related biological pathways as regulators of transcriptional progression. Sirtuins play fundamental roles in carcinogenesis and maintenance of the malignant phenotype, mainly participating in cancer cell viability, apoptosis, metastasis, and tumorigenesis. Although sirtuin family members have a high degree of homology, they may play different roles in various kinds of cancer. This review highlights their fundamental roles in tumorigenesis and cancer development and provides a critical discussion of their dual roles in cancer, namely, as tumor promoters or tumor suppressors.

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Provenance

Source: OpenAlex
DOI: 10.3390/cancers11121949
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Fetched: 2026-07-08 MST

Cite this

APA

Zhao, E., Hou, J., Ke, X., Abbas, M.N., Kausar, S., Zhang, L., & Cui, H. (2019). The Roles of Sirtuin Family Proteins in Cancer Progression. <em>Cancers</em>. https://doi.org/10.3390/cancers11121949

Vancouver

Zhao E, Hou J, Ke X, Abbas MN, Kausar S, Zhang L, et al. The Roles of Sirtuin Family Proteins in Cancer Progression. Cancers. 2019. doi:10.3390/cancers11121949.

BibTeX

@article{erhu2019TheRol, title = {The Roles of Sirtuin Family Proteins in Cancer Progression}, author = {Erhu Zhao and Jianbing Hou and Xiaoxue Ke and Muhammad Nadeem Abbas and Saima Kausar and Lei Zhang and Hongjuan Cui}, journal = {Cancers}, year = {2019}, doi = {10.3390/cancers11121949}, }