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The RecQ DNA Helicases in DNA Repair

Kara A. Bernstein, Serge Gangloff, Rodney Rothstein

Annual Review of Genetics · 2010 · ▲ 298 citations

Genomic instability Telomere attrition Human

Abstract

The RecQ helicases are conserved from bacteria to humans and play a critical role in genome stability. In humans, loss of RecQ gene function is associated with cancer predisposition and/or premature aging. Recent experiments have shown that the RecQ helicases function during distinct steps during DNA repair; DNA end resection, displacement-loop (D-loop) processing, branch migration, and resolution of double Holliday junctions (dHJs). RecQ function in these different processing steps has important implications for its role in repair of double-strand breaks (DSBs) that occur during DNA replication and meiosis, as well as at specific genomic loci such as telomeres.

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Provenance

Source: OpenAlex
DOI: 10.1146/annurev-genet-102209-163602
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Fetched: 2026-06-09 MST

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APA

Bernstein, K.A., Gangloff, S., & Rothstein, R. (2010). The RecQ DNA Helicases in DNA Repair. <em>Annual Review of Genetics</em>. https://doi.org/10.1146/annurev-genet-102209-163602

Vancouver

Bernstein KA, Gangloff S, Rothstein R. The RecQ DNA Helicases in DNA Repair. Annual Review of Genetics. 2010. doi:10.1146/annurev-genet-102209-163602.

BibTeX

@unpublished{kara2010TheRec, title = {The RecQ DNA Helicases in DNA Repair}, author = {Kara A. Bernstein and Serge Gangloff and Rodney Rothstein}, journal = {Annual Review of Genetics}, year = {2010}, doi = {10.1146/annurev-genet-102209-163602}, }