The recent research progress on traditional Chinese medicine application in Parkinson's disease: a review.

<h4>Background</h4>Parkinson's disease (PD) is a type of neurodegenerative diseases with the characterized by static tremors, bradykinesia, and muscle rigidity. This is mainly caused by the degradation and death of dopaminergic neurons in the substantia nigra, severely affects the health of the elderly no matter in developing or developed countries. In recent years, Traditional Chinese medicine (TCM) has made significant advances in the treatment and application of PD with its unique advantages in recent years.<h4>Methods</h4>A systematic search of the extant literature, published between 2021 and 2026, was conducted in the following databases: PubMed, Embase, Scopus, and Web of Science. The search was conducted using the keywords "Traditional Chinese Medicine", "Parkinson's disease", "preclinical application", "clinical application". We summarized the recent TCM application in PD including preclinical and clinical application and the underlying mechanisms were summarized, and discussed the possible application limitations.<h4>Results and conclusion</h4>TCM exhibits significant potential for preclinical and clinical application in PD. The ongoing resolution of current application limitations, including the pharmacological substance basis and the mechanism of TCM, the establishment of quality standards for TCM, and the conducting the standardized clinical trials, will result in significant progress in the application of TCM in PD.