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The NAD <sup>+</sup> Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC derived Cortical Organoid of Alpers' Disease

Yu Hong, Zhuoyuan Zhang, Tsering Yangzom, Anbin Chen, Bjørn Christian Lundberg, Evandro Fei Fang, Richard Siller, Gareth J. Sullivan, J Zeman, Charalampos Tzoulis, Laurence A. Bindoff, Kristina Xiao Liang

International Journal of Biological Sciences · 2024 · ▲ 8 citations

Abstract

models of Alpers' disease; this first-in-its-kind stem cell platform for Alpers' syndrome enables therapeutic exploration and has identified NR as a viable drug candidate for Alpers' disease and, potentially, other mitochondrial diseases with similar causes.

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Provenance

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OpenAlex
DOI
10.7150/ijbs.91624
Canonical
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2026-07-05 MST

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APA
Hong, Y., Zhang, Z., Yangzom, T., Chen, A., Lundberg, B.C., Fang, E.F., Siller, R., Sullivan, G.J., Zeman, J., Tzoulis, C., Bindoff, L.A., &amp; Liang, K.X. (2024). The NAD <sup>+</sup> Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC derived Cortical Organoid of Alpers' Disease. <em>International Journal of Biological Sciences</em>. https://doi.org/10.7150/ijbs.91624
Vancouver
Hong Y, Zhang Z, Yangzom T, Chen A, Lundberg BC, Fang EF, et al. The NAD <sup>+</sup> Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC derived Cortical Organoid of Alpers' Disease. International Journal of Biological Sciences. 2024. doi:10.7150/ijbs.91624.
BibTeX
@article{yu2024TheNAD, title = {The NAD <sup>+</sup> Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC derived Cortical Organoid of Alpers' Disease}, author = {Yu Hong and Zhuoyuan Zhang and Tsering Yangzom and Anbin Chen and Bjørn Christian Lundberg and Evandro Fei Fang and Richard Siller and Gareth J. Sullivan and J Zeman and Charalampos Tzoulis and Laurence A. Bindoff and Kristina Xiao Liang}, journal = {International Journal of Biological Sciences}, year = {2024}, doi = {10.7150/ijbs.91624}, }

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