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The essence of senescence: Figure 1.

Thomas Kuilman, Chrysiis Michaloglou, Wolter J. Mooi, Daniel S. Peeper

Genes & Development · 2010 · ▲ 2,011 citations

Cellular senescence Cell culture / in vitro In vitro Review

Abstract

Almost half a century after the first reports describing the limited replicative potential of primary cells in culture, there is now overwhelming evidence for the existence of "cellular senescence" in vivo. It is being recognized as a critical feature of mammalian cells to suppress tumorigenesis, acting alongside cell death programs. Here, we review the various features of cellular senescence and discuss their contribution to tumor suppression. Additionally, we highlight the power and limitations of the biomarkers currently used to identify senescent cells in vitro and in vivo.

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Provenance

Source: OpenAlex
DOI: 10.1101/gad.1971610
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Fetched: 2026-05-31 MST

Cite this

APA

Kuilman, T., Michaloglou, C., Mooi, W.J., & Peeper, D.S. (2010). The essence of senescence: Figure 1. <em>Genes & Development</em>. https://doi.org/10.1101/gad.1971610

Vancouver

Kuilman T, Michaloglou C, Mooi WJ, Peeper DS. The essence of senescence: Figure 1. Genes & Development. 2010. doi:10.1101/gad.1971610.

BibTeX

@article{thomas2010Theess, title = {The essence of senescence: Figure 1.}, author = {Thomas Kuilman and Chrysiis Michaloglou and Wolter J. Mooi and Daniel S. Peeper}, journal = {Genes & Development}, year = {2010}, doi = {10.1101/gad.1971610}, }