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The aging endothelium

Ka Ka Ting, Paul R. Coleman, Yang Zhao, Mathew Alexander Vadas, Jennifer R. Gamble

Vascular Biology · 2021 · ▲ 38 citations

Cellular senescence Senolytics

Abstract

Cellular senescence is now recognized as one of the telomere attrition, cellular senescence)." style="text-decoration:underline dotted; text-underline-offset:2px; cursor:help;">hallmarks of aging. Herein, we examine current findings on senescence of the vascular endothelium and its impacts on age-related vascular diseases. Endothelial senescence can result in systemic metabolic changes, implicating senescence in chronic diseases such as diabetes, obesity and atherosclerosis. Senolytics, drugs that eliminate senescent cells, afford new therapeutic strategies for control of these chronic diseases.

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Provenance

Source: OpenAlex
DOI: 10.1530/vb-20-0013
Canonical: link ↗
Fetched: 2026-09-26 MST

Cite this

APA

Ting, K.K., Coleman, P.R., Zhao, Y., Vadas, M.A., & Gamble, J.R. (2021). The aging endothelium. <em>Vascular Biology</em>. https://doi.org/10.1530/vb-20-0013

Vancouver

Ting KK, Coleman PR, Zhao Y, Vadas MA, Gamble JR. The aging endothelium. Vascular Biology. 2021. doi:10.1530/vb-20-0013.

BibTeX

@article{ka2021Theagi, title = {The aging endothelium}, author = {Ka Ka Ting and Paul R. Coleman and Yang Zhao and Mathew Alexander Vadas and Jennifer R. Gamble}, journal = {Vascular Biology}, year = {2021}, doi = {10.1530/vb-20-0013}, }