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Skeletal muscle aging – Stem cells in the spotlight

Henriette Henze, Marie Juliane Jung, Hellen E. Ahrens, Saskia Steiner, Julia von Maltzahn

Mechanisms of Ageing and Development · 2020 · ▲ 31 citations

Stem-cell exhaustion

Abstract

Aging is characterized by a progressive decline in tissue and organ function often linked to a reduced stem cell functionality, a cell population important for regeneration. Skeletal muscle mass and regenerative capacity decrease with advancing age. Muscle stem cells, also termed satellite cells, are a prerequisite for regeneration of skeletal muscle. Their functionality declines with increasing age, driven by intrinsic changes and changes in the stem cell niche. Here, we discuss the current understanding how muscle stem cells are affected during aging. The aging associated alterations include among others upregulation of developmental pathways in aged muscle stem cells and changes in the extracellular matrix.

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Provenance

Source: OpenAlex
DOI: 10.1016/j.mad.2020.111283
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Fetched: 2026-08-03 MST

Cite this

APA

Henze, H., Jung, M.J., Ahrens, H.E., Steiner, S., & Maltzahn, J.V. (2020). Skeletal muscle aging – Stem cells in the spotlight. <em>Mechanisms of Ageing and Development</em>. https://doi.org/10.1016/j.mad.2020.111283

Vancouver

Henze H, Jung MJ, Ahrens HE, Steiner S, Maltzahn JV. Skeletal muscle aging – Stem cells in the spotlight. Mechanisms of Ageing and Development. 2020. doi:10.1016/j.mad.2020.111283.

BibTeX

@article{henriette2020Skelet, title = {Skeletal muscle aging – Stem cells in the spotlight}, author = {Henriette Henze and Marie Juliane Jung and Hellen E. Ahrens and Saskia Steiner and Julia von Maltzahn}, journal = {Mechanisms of Ageing and Development}, year = {2020}, doi = {10.1016/j.mad.2020.111283}, }