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Sirtuins in Women's Health.

Madhusudhana R, Hamza A, Boyle E, Pollock S, Cen Y.

Pharmaceuticals (Basel, Switzerland) · 2025

Genomic instability Deregulated nutrient-sensing Human Review

Abstract

The human sirtuins (SIRT1-SIRT7) are NAD+-dependent protein deacylases that orchestrate key cellular events such as metabolism, stress response, DNA repair, and aging. Accumulating evidence highlights their central role in women's health. This review integrates recent insights into the roles of sirtuins across the female lifespan and their involvement in reproductive, metabolic, oncologic, and age-related disorders. Sirtuins regulate reproductive function, pregnancy outcomes, and hormone-dependent cancers. Their decline with aging contributes to menopausal and metabolic complications. Pharmacological interventions that enhance sirtuin activity, such as NAD+ precursors and SIRT1 activators, show promise in mitigating these conditions. Collectively, understanding the isoform- and tissue-specific roles of sirtuins provides a foundation for developing therapeutics to improve the lifespan and healthspan of women.

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Provenance

Source: Europe PMC
DOI: 10.3390/ph18121859
Canonical: link ↗
Fetched: 2026-07-02 MST

Cite this

APA

R, M., A, H., E, B., S, P., & Y., C. (2025). Sirtuins in Women's Health. Pharmaceuticals (Basel, Switzerland). https://doi.org/10.3390/ph18121859

Vancouver

R M, A H, E B, S P, Y. C. Sirtuins in Women's Health. Pharmaceuticals (Basel, Switzerland). 2025. doi:10.3390/ph18121859.

BibTeX

@article{madhusudhana2025Sirtui, title = {Sirtuins in Women's Health.}, author = {Madhusudhana R and Hamza A and Boyle E and Pollock S and Cen Y.}, journal = {Pharmaceuticals (Basel, Switzerland)}, year = {2025}, doi = {10.3390/ph18121859}, }