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Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis

Yu Sun, Wenzhou Liu, Tao Liu, Feng Xu, Nuo Yang, Hua‐Fu Zhou

Journal of Receptors and Signal Transduction · 2015 · ▲ 1,869 citations

Cellular senescence Altered intercellular communication Review

Abstract

The generic mitogen-activated protein kinases (MAPK) signaling pathway is shared by four distinct cascades, including the extracellular signal-related kinases (ERK1/2), Jun amino-terminal kinases (JNK1/2/3), p38-MAPK and ERK5. Mitogen-activated protein kinases/extracellular signal-regulated kinase (MAPK/ERK) pathway is reported to be associated with the cell proliferation, differentiation, migration, senescence and apoptosis. The literatures were searched extensively and this review was performed to review the role of MAPK/ERK signaling pathway in cell proliferation, differentiation, migration, senescence and apoptosis.

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Provenance

Source: OpenAlex
DOI: 10.3109/10799893.2015.1030412
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Fetched: 2026-05-31 MST

Cite this

APA

Sun, Y., Liu, W., Liu, T., Xu, F., Yang, N., & Zhou, H. (2015). Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis. <em>Journal of Receptors and Signal Transduction</em>. https://doi.org/10.3109/10799893.2015.1030412

Vancouver

Sun Y, Liu W, Liu T, Xu F, Yang N, Zhou H. Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis. Journal of Receptors and Signal Transduction. 2015. doi:10.3109/10799893.2015.1030412.

BibTeX

@article{yu2015Signal, title = {Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis}, author = {Yu Sun and Wenzhou Liu and Tao Liu and Feng Xu and Nuo Yang and Hua‐Fu Zhou}, journal = {Journal of Receptors and Signal Transduction}, year = {2015}, doi = {10.3109/10799893.2015.1030412}, }