Preprint · OA
via OpenAlex
Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages
Anthony J. Covarrubias, Abhijit Kale, Rosalba Perrone, Jose Alberto Lopez-Dominguez, Angela Oliveira Pisco, Herbert G. Kasler, Mark S. Schmidt, Indra Heckenbach, Ryan Kwok, Christopher D. Wiley, Hoi Shan Wong, Eddy Gibbs, Shankar S. Iyer, Nathan Basisty, Qiuxia Wu
Nature Metabolism · 2020 · ▲ 428 citations
Abstract
A 2020 *Nature Metabolism* study shows that senescent cells drive age-related tissue NAD+ decline through the activation of CD38+ macrophages.
◌ CITATION ONLY
Full text is not openly licensed for redistribution here. Read it at the source:
Provenance
- Source
- OpenAlex
- DOI
- 10.1038/s42255-020-00305-3
- Canonical
- link ↗
- Fetched
- 2026-09-30 MST
Cite this
APA
Covarrubias, A.J., Kale, A., Perrone, R., Lopez-Dominguez, J.A., Pisco, A.O., Kasler, H.G., Schmidt, M.S., Heckenbach, I., Kwok, R., Wiley, C.D., Wong, H.S., Gibbs, E., Iyer, S.S., Basisty, N., Wu, Q., Kim, I., Silva, E., Vitangcol, K., Shin, K., & Lee, Y. (2020). Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages. <em>Nature Metabolism</em>. https://doi.org/10.1038/s42255-020-00305-3
Vancouver
Covarrubias AJ, Kale A, Perrone R, Lopez-Dominguez JA, Pisco AO, Kasler HG, et al. Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages. Nature Metabolism. 2020. doi:10.1038/s42255-020-00305-3.
BibTeX
@unpublished{anthony2020Senesc,
title = {Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages},
author = {Anthony J. Covarrubias and Abhijit Kale and Rosalba Perrone and Jose Alberto Lopez-Dominguez and Angela Oliveira Pisco and Herbert G. Kasler and Mark S. Schmidt and Indra Heckenbach and Ryan Kwok and Christopher D. Wiley and Hoi Shan Wong and Eddy Gibbs and Shankar S. Iyer and Nathan Basisty and Qiuxia Wu and Ik-Jung Kim and Elena Silva and Kaitlyn Vitangcol and Kyong‐Oh Shin and Yong-Moon Lee and Rebeccah R. Riley and Issam Ben‐Sahra and Mélanie Ott and Birgit Schilling and Morten Scheibye‐Knudsen},
journal = {Nature Metabolism},
year = {2020},
doi = {10.1038/s42255-020-00305-3},
}
Research neighborhood
References, citing works, and semantically nearest findings. Click a node to open it.
Related findings
Biochemical and Biophysical Research Communications 2019
Open access · CC-BY
The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline
Nature Methods 2022
Open access · OA
Museum of spatial transcriptomics
Ageing Research Reviews 2016
Citation only
Senescent endothelial cells: Potential modulators of immunosenescence and ageing
Nature Aging 2023
Preprint · OA
Senescent cells, senolytics and tissue repair: the devil may be in the dosing
Chinese Medicine 2014
Open access · CC-BY
Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis
Diabetes 2009
Open access · CC-BY