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Senescence and Cancer: Role of Nitric Oxide (NO) in SASP

Nesrine Mabrouk, S Ghione, Véronique Laurens, Stéphanie Plenchette, Ali Bettaı̈eb, Catherine Paul

Cancers · 2020 · ▲ 25 citations

Cellular senescence Review

Abstract

Cellular senescence is a cell state involved in both physiological and pathological processes such as age-related diseases and cancer. While the mechanism of senescence is now well known, its role in tumorigenesis still remains very controversial. The positive and negative effects of senescence on tumorigenesis depend largely on the diversity of the senescent phenotypes and, more precisely, on the senescence-associated secretory phenotype (SASP). In this review, we discuss the modulatory effect of nitric oxide (NO) in SASP and the possible benefits of the use of NO donors or iNOS inducers in combination with senotherapy in cancer treatment.

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Provenance

Source: OpenAlex
DOI: 10.3390/cancers12051145
Canonical: link ↗
Fetched: 2026-06-07 MST

Cite this

APA

Mabrouk, N., Ghione, S., Laurens, V., Plenchette, S., Bettaı̈eb, A., & Paul, C. (2020). Senescence and Cancer: Role of Nitric Oxide (NO) in SASP. <em>Cancers</em>. https://doi.org/10.3390/cancers12051145

Vancouver

Mabrouk N, Ghione S, Laurens V, Plenchette S, Bettaı̈eb A, Paul C. Senescence and Cancer: Role of Nitric Oxide (NO) in SASP. Cancers. 2020. doi:10.3390/cancers12051145.

BibTeX

@article{nesrine2020Senesc, title = {Senescence and Cancer: Role of Nitric Oxide (NO) in SASP}, author = {Nesrine Mabrouk and S Ghione and Véronique Laurens and Stéphanie Plenchette and Ali Bettaı̈eb and Catherine Paul}, journal = {Cancers}, year = {2020}, doi = {10.3390/cancers12051145}, }