Citation only
via OpenAlex
Sarcopenia != Dynapenia
Brian C. Clark, Todd Matthew Manini
The Journals of Gerontology Series A · 2008 · ▲ 872 citations
Abstract
Maximal voluntary force (strength) production declines with age and contributes to physical dependence and mortality. Consequently, a great deal of research has focused on identifying strategies to maintain muscle mass during the aging process and elucidating key molecular pathways of atrophy, with the rationale that the loss of strength is primarily a direct result of the age-associated declines in mass (sarcopenia). However, recent evidence questions this relationship and in this Green Banana article we argue the role of sarcopenia in mediating the age-associated loss of strength (which we will coin as dynapenia) does not deserve the attention it has attracted in both the scientific literature and popular press. Rather, we propose that alternative mechanisms underlie dynapenia (i.e., alterations in contractile properties or neurologic function), and urge that greater attention be paid to these variables in determining their role in dynapenia.
◌ CITATION ONLY
Full text is not openly licensed for redistribution here. Read it at the source:
Provenance
- Source
- OpenAlex
- DOI
- 10.1093/gerona/63.8.829
- Canonical
- link ↗
- Fetched
- 2026-10-17 MST
Cite this
APA
Clark, B.C., & Manini, T.M. (2008). Sarcopenia != Dynapenia. <em>The Journals of Gerontology Series A</em>. https://doi.org/10.1093/gerona/63.8.829
Vancouver
Clark BC, Manini TM. Sarcopenia != Dynapenia. The Journals of Gerontology Series A. 2008. doi:10.1093/gerona/63.8.829.
BibTeX
@article{brian2008Sarcop,
title = {Sarcopenia != Dynapenia},
author = {Brian C. Clark and Todd Matthew Manini},
journal = {The Journals of Gerontology Series A},
year = {2008},
doi = {10.1093/gerona/63.8.829},
}
Research neighborhood
References, citing works, and semantically nearest findings. Click a node to open it.
Related findings
VU Research Portal 2006
Preprint
Interleukin-6, C-reactive protein and α1-antichymotrypsin as determinants of loss of muscle strength and muscle mass (sarcopenia): the Longitudinal Aging Study Amsterdam (LASA).
Karolinska Institutet 2021
Open access · US-GOV
A Longitudinal Approach to Characterize Loss of Muscle Mass and Function in Ageing Humans
Zenodo (CERN European Organization for Nuclear Research) 2018
Preprint · CC-BY
Mitochondrial Paths to Sarcopenia – A Refined Short Review
Ageing Research Reviews 2026
Open access · CC-BY
Age-related sarcopenia and the gut microbiome: mechanistic insights into the gut-muscle axis and potential microbiome based therapeutic interventions
Escola Superior de Saúde - Universidade do Algarve 2026
Open access · US-GOV
Effects of Magnesium Supplementation on Muscle Strength, Muscle Mass, and Physical Performance in Sarcopenic Individuals
The American Journal of Medicine 2006
Citation only