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Role of advanced glycation end products in cellular signaling

Christiane Ott, Kathleen Jacobs, Elisa Haucke, Anne Navarrete Santos, Tilman Grune, Andreas Simm

Redox Biology · 2014 · ▲ 1,128 citations

Altered intercellular communication Chronic inflammation Review

Abstract

Improvements in health care and lifestyle have led to an elevated lifespan and increased focus on age-associated diseases, such as neurodegeneration, cardiovascular disease, frailty and arteriosclerosis. In all these chronic diseases protein, lipid or nucleic acid modifications are involved, including cross-linked and non-degradable aggregates, such as advanced glycation end products (AGEs). Formation of endogenous or uptake of dietary AGEs can lead to further protein modifications and activation of several inflammatory signaling pathways. This review will give an overview of the most prominent AGE-mediated signaling cascades, AGE receptor interactions, prevention of AGE formation and the impact of AGEs during pathophysiological processes.

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Provenance

Source: OpenAlex
DOI: 10.1016/j.redox.2013.12.016
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Fetched: 2026-08-04 MST

Cite this

APA

Ott, C., Jacobs, K., Haucke, E., Santos, A.N., Grune, T., & Simm, A. (2014). Role of advanced glycation end products in cellular signaling. <em>Redox Biology</em>. https://doi.org/10.1016/j.redox.2013.12.016

Vancouver

Ott C, Jacobs K, Haucke E, Santos AN, Grune T, Simm A. Role of advanced glycation end products in cellular signaling. Redox Biology. 2014. doi:10.1016/j.redox.2013.12.016.

BibTeX

@article{christiane2014Roleof, title = {Role of advanced glycation end products in cellular signaling}, author = {Christiane Ott and Kathleen Jacobs and Elisa Haucke and Anne Navarrete Santos and Tilman Grune and Andreas Simm}, journal = {Redox Biology}, year = {2014}, doi = {10.1016/j.redox.2013.12.016}, }