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Reframing diet assessment for geroscience: development and preliminary validation of an anti-aging dietary score

Shixing Feng, Tianyi Wang, Jinlong Yan, Chaohui Yin, Baoyan Chen, Miao Shi, Jialin Liu, Huaqiang Zhai

npj Science of Food · 2026

Cellular senescence Altered intercellular communication

Abstract

Conventional dietary indices often fail to align with aging biology. To bridge this mechanistic gap, we propose the Nutrient-Signaling-Senescence (NSS) axis as an integrative framework. Based on this foundation, we develop the anti-aging dietary score (AADS). Preliminary validation using NHANES data demonstrates that a higher AADS is significantly associated with lower PhenoAge acceleration, performing comparably to established indices. This framework enables translating aging biology into population-based research.

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Provenance

Source: OpenAlex
DOI: 10.1038/s41538-026-00960-y
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Fetched: 2026-10-23 MST

Cite this

APA

Feng, S., Wang, T., Yan, J., Yin, C., Chen, B., Shi, M., Liu, J., & Zhai, H. (2026). Reframing diet assessment for geroscience: development and preliminary validation of an anti-aging dietary score. <em>npj Science of Food</em>. https://doi.org/10.1038/s41538-026-00960-y

Vancouver

Feng S, Wang T, Yan J, Yin C, Chen B, Shi M, et al. Reframing diet assessment for geroscience: development and preliminary validation of an anti-aging dietary score. npj Science of Food. 2026. doi:10.1038/s41538-026-00960-y.

BibTeX

@article{shixing2026Refram, title = {Reframing diet assessment for geroscience: development and preliminary validation of an anti-aging dietary score}, author = {Shixing Feng and Tianyi Wang and Jinlong Yan and Chaohui Yin and Baoyan Chen and Miao Shi and Jialin Liu and Huaqiang Zhai}, journal = {npj Science of Food}, year = {2026}, doi = {10.1038/s41538-026-00960-y}, }