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Protein homeostasis in aging and cancer

Xiao‐Qiong Chen, Tao Shen, Shaojun Fang, Xiao-Min Sun, Guoyu Li, Yunfeng Li

Frontiers in Cell and Developmental Biology · 2023 · ▲ 44 citations

Loss of proteostasis Human Review

Abstract

Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis, or proteostasis, is a universal hallmark of both the aging process and cancer, a comprehensive understanding of the proteostasis system and its roles in aging and cancer will shed new light on how we can improve health and quality of life for older individuals. In this review, we summarize the regulatory mechanisms of proteostasis and discuss the relationship between proteostasis and aging and age-related diseases, including cancer. Furthermore, we highlight the clinical application value of proteostasis maintenance in delaying the aging process and promoting long-term health.

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Provenance

Source: OpenAlex
DOI: 10.3389/fcell.2023.1143532
Canonical: link ↗
Fetched: 2026-06-12 MST

Cite this

APA

Chen, X., Shen, T., Fang, S., Sun, X., Li, G., & Li, Y. (2023). Protein homeostasis in aging and cancer. <em>Frontiers in Cell and Developmental Biology</em>. https://doi.org/10.3389/fcell.2023.1143532

Vancouver

Chen X, Shen T, Fang S, Sun X, Li G, Li Y. Protein homeostasis in aging and cancer. Frontiers in Cell and Developmental Biology. 2023. doi:10.3389/fcell.2023.1143532.

BibTeX

@article{xiaoqiong2023Protei, title = {Protein homeostasis in aging and cancer}, author = {Xiao‐Qiong Chen and Tao Shen and Shaojun Fang and Xiao-Min Sun and Guoyu Li and Yunfeng Li}, journal = {Frontiers in Cell and Developmental Biology}, year = {2023}, doi = {10.3389/fcell.2023.1143532}, }