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Proline metabolism regulates replicative lifespan in the yeast Saccharomyces cerevisiae

Yukio Mukai, Yuka Kamei, Xu Liu, Shan Jiang, Yukiko Sugimoto, Noreen Suliani Mat Nanyan, Daisuke Watanabe, Hiroshi Takagi

Microbial Cell · 2019 · ▲ 40 citations

Deregulated nutrient-sensing Yeast

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Abstract

, resulting in a short lifespan. Thus, the intracellular proline levels at stationary phase was positively correlated with the replicative lifespan. Furthermore, multivariate analysis of amino acids in yeast mutants deficient in proline metabolism showed characteristic metabolic profiles coincident with longevity: acidic and basic amino acids and branched-chain amino acids positively contributed to the replicative lifespan. These results allude to proline metabolism having a physiological role in maintaining the lifespan of yeast cells.

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Provenance

Source: OpenAlex
DOI: 10.15698/mic2019.10.694
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Fetched: 2026-07-06 MST

Cite this

APA

Mukai, Y., Kamei, Y., Liu, X., Jiang, S., Sugimoto, Y., Nanyan, N.S.M., Watanabe, D., & Takagi, H. (2019). Proline metabolism regulates replicative lifespan in the yeast Saccharomyces cerevisiae. <em>Microbial Cell</em>. https://doi.org/10.15698/mic2019.10.694

Vancouver

Mukai Y, Kamei Y, Liu X, Jiang S, Sugimoto Y, Nanyan NSM, et al. Proline metabolism regulates replicative lifespan in the yeast Saccharomyces cerevisiae. Microbial Cell. 2019. doi:10.15698/mic2019.10.694.

BibTeX

@article{yukio2019Prolin, title = {Proline metabolism regulates replicative lifespan in the yeast Saccharomyces cerevisiae}, author = {Yukio Mukai and Yuka Kamei and Xu Liu and Shan Jiang and Yukiko Sugimoto and Noreen Suliani Mat Nanyan and Daisuke Watanabe and Hiroshi Takagi}, journal = {Microbial Cell}, year = {2019}, doi = {10.15698/mic2019.10.694}, }