Poor Appetite & Aging: The Role of Physical Activity under a Geroscience Perspective

oor appetite is a very prevalent condition in old adulthood, reaching about 30% of older people; higher prevalence can be found in specific geriatric populations, such as hospitalized individuals and nursing home residents.Poor appetite is associated with several adverse health events, such as frailty and sarcopenia, mood issues, and even mortality, including in the absence of overt clinical signs of malnutrition (eg, weight loss) (1).For a long time considered as a natural consequence of the aging process, loss of appetite received only marginal attention from the scientific community and it is currently under-evaluated, under-diagnosed and undertreated in clinical practice.The multidimensional etiology of this condition renders it difficult to have a symptomatic drug to treat it.As a consequence, no medication has an indication for treating poor/loss of appetite to date.Furthermore, preventive strategies to avoid the onset of appetite loss have been particularly neglected in the scientific literature.Recent advances in the field of aging research pave the way for a new approach to improve the understanding on poor appetite in older people.Of particular interest is the birth of Geroscience (2), which main hypothesis relies on two fundamental pillars: 1.There is an interplay between the biology of aging and the biology of chronic conditions, including diseases (eg, cardiometabolic, cancers), geriatric syndromes (eg, frailty, poor appetite/anorexia of aging), and functions (eg, mobility, cognition); 2. By intervening and