[P1–165]: BLOOD ALPHA‐SYNUCLEIN IN ALZHEIMER'S DISEASE

The accumulation of α-synuclein aggregates is the hallmark of Parkinson's disease while amyloid aggregates for Alzheimer's Disease. Numerous studies reported crosstalk of these proteinopathies. Serum was extracted from AD(n=40), MCI (n=20) and age matched healthy control(n=40) at two time points. Alpha-synuclein level was quantified with ELISA and confirmed with western blot. Mean α-synuclein was significantly higher in 25% patients of Alzheimer's Disease while only in 10% cases of MCI. The difference between in significant cases with control group was 1.5-fold. And this increase of alpha-synuclein was not correlated with disease duration, onset age of disease or MCI score. Overexpressed Levels of α-synuclein in 25% patients of Alzheimer's Disease, denotes its confirmation in Alzheimer's Disease involvement with unknown pathophysiology.