OSTEOPOROSIS

Article1 December 1947OSTEOPOROSISFULLER ALBRIGHT, M.D.FULLER ALBRIGHT, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-27-6-861 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDR. WARING, MEMBERS OF THE AMERICAN COLLEGE OF PHYSICIANS, AND GUESTS!Osler is quoted as saying: "If you know syphilis, you know internal medicine." Time and medicine have marched on. I think if Osler were here today he would agree to amend his statement to read: "If you know the adrenal cortex, you know internal medicine." With this in mind, I first chose, as the subject of this lecture, "Adrenal Cortical Syndromes and Their Diagnoses." But I soon found I did not know the adrenal cortex!I think I do understand a few things about osteoporosis, which, like everything else,...Bibliography1. ALBRIGHTSMITHRICHARDSON FPHAM: Post-menopausal osteoporosis: its clinical features, Jr. Am. Med. Assoc., 1940, cxvi, 2465-2474. Google Scholar2. ALBRIGHT F: Cushing's syndrome: its pathological physiology, its relationship to the adreno-genital syndrome, and its connection with the problem of the reaction of the body to injurious agents ("alarm reaction" of Selye), The Harvey Lecture Series, 1942-1943, xxxviii, 123-186. Google Scholar3. ALBRIGHTBURNETTPARSONREIFENSTEINROOS FCHWECA: Osteomalacia and late rickets: the various etiologies met in the United States with emphasis on that resulting from a specific form of renal acidosis, the therapeutic indications for each etiological sub-group, and the relationship between osteomalacia and Milkman's syndrome, Medicine, 1946, xxv, 399-479. Google Scholar4. ALBRIGHT F: The effect of hormones on osteogenesis in man, Recent Progress in Hormone Research: Proceedings of the Laurentian Conference, 1947, i, 293-353. Google Scholar5. REIFENSTEINALBRIGHT ECF: The metabolic effects of steroid hormones in osteoporosis, Jr. Clin. Invest., 1947, xxvi, 24-56. CrossrefGoogle Scholar6. REIFENSTEINALBRIGHTWELLS ECFSL: The accumulation, interpretation, and presentation of data pertaining to metabolic balances, notably those of calcium, phosphorus, and nitrogen, Jr. Clin. Endocrinol., 1945, v, 367-395. CrossrefGoogle Scholar7. ALBRIGHTBURNETTCOPEPARSON FCHOW: Acute atrophy of bone (osteoporosis) simulating hyperparathyroidism, Jr. Clin. Endocrinol., 1941, i, 711-716. CrossrefGoogle Scholar8. ALBRIGHTSMITHFRASER FPHR: A syndrome characterized by primary ovarian insufficiency and decreased stature: report of 11 cases with a digression on hormonal control of axillary and pubic hair, Am. Jr. Med. Sci., 1942, cciv, 625-648. CrossrefGoogle Scholar9. SELYE H: The general adaptation syndrome and the diseases of adaptation, Jr. Clin. Endocrinol., 1946, vi, 117-230. CrossrefGoogle Scholar10. TALBOTSALTZMANWIXOMWOLFE NBAHRLJK: The colorimetric assay of urinary corticosteroid-like substances, Jr. Biol. Chem., 1945, clx, 535-546. CrossrefGoogle Scholar11. DEMPSEY EW: Personal communication. Google Scholar12. VENNINGBROWNE EHJS: Conference on Metabolic Aspects of Convalescence, Fourteenth Meeting, Nov. 12-13, 1946, New York, 186-187. Google Scholar13. TALBOTALBRIGHTSALTZMANZYGMUNTOWICZWIXOM NBFAHAR: The excretion of 11-oxycorticosteroid-like substances by normal and abnormal subjects (In press). Jr. Clin. Endocrinol., 1947, vii, 331-350. CrossrefGoogle Scholar14. EMERSONBECKMAN KWW: Calcium metabolism in nephrosis; I. a description of an abnormality in calcium metabolism in children with nephrosis, Jr. Clin. Invest., 1945, xxiv, 564-572. CrossrefGoogle Scholar15. FORBESALBRIGHTREIFENSTEINBRYANTCOXDEMPSEY APFECDFLDEF: Studies on the fate of intravenously administered plasma protein (Submitted for publication). Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*The John Phillips Memorial Lecture read before the American College of Physicians in Chicago on April 30, 1947. For further studies by the author and his colleagues on the subject of osteoporosis the reader is referred to the following references in the bibliography.1, 2, 3, 4, 5, 6, 7From the Medical Service of the Massachusetts General Hospital and the Department of Medicine of the Harvard Medical School, Boston, Massachusetts.The expense of these studies was partly defrayed by grants from the Josiah Macy, Jr. Foundation, the Rockefeller Foundation, the National Advisory Cancer Council, Ayerst, McKenna and Harrison, Ltd., and the American Cancer Society on the recommendation of the Committee on Growth of the National Research Council. A bed supported by the Mallinckrodt Chemical Company on the Metabolic Ward was used for part of these studies.The part of this address which has to do with internal skeletal dynamics and osteoporosis of old age was read at the Ether Centenary at the Massachusetts General Hospital on October 14, 1946. 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