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Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures
Yasir Elhassan, Katarína Kľučková, Rachel S. Fletcher, Mark S. Schmidt, Antje Garten, Craig Doig, David M. Cartwright, Lucy Oakey, Claire V. Burley, Ned Jenkinson, Martin Wilson, Samuel J. E. Lucas, İldem Akerman, Alex P. Seabright, Yu‐Chiang Lai
Cell Reports · 2019 · ▲ 432 citations
Abstract
metabolome, evident by increased nicotinic acid adenine dinucleotide and nicotinamide clearance products. Muscle RNA sequencing revealed NR-mediated downregulation of energy metabolism and mitochondria pathways, without altering mitochondrial bioenergetics. NR also depressed levels of circulating inflammatory cytokines. Our data establish that oral NR is available to aged human muscle and identify anti-inflammatory effects of NR.
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- 10.1016/j.celrep.2019.07.043
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- 2026-06-16 MST
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APA
Elhassan, Y., Kľučková, K., Fletcher, R.S., Schmidt, M.S., Garten, A., Doig, C., Cartwright, D.M., Oakey, L., Burley, C.V., Jenkinson, N., Wilson, M., Lucas, S.J.E., Akerman, �., Seabright, A.P., Lai, Y., Tennant, D.A., Nightingale, P., Wallis, G.A., Manolopoulos, K., & Brenner, C. (2019). Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. <em>Cell Reports</em>. https://doi.org/10.1016/j.celrep.2019.07.043
Vancouver
Elhassan Y, Kľučková K, Fletcher RS, Schmidt MS, Garten A, Doig C, et al. Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. Cell Reports. 2019. doi:10.1016/j.celrep.2019.07.043.
BibTeX
@article{yasir2019Nicoti,
title = {Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures},
author = {Yasir Elhassan and Katarína Kľučková and Rachel S. Fletcher and Mark S. Schmidt and Antje Garten and Craig Doig and David M. Cartwright and Lucy Oakey and Claire V. Burley and Ned Jenkinson and Martin Wilson and Samuel J. E. Lucas and İldem Akerman and Alex P. Seabright and Yu‐Chiang Lai and Daniel A. Tennant and Peter Nightingale and Gareth A. Wallis and Konstantinos Manolopoulos and Charles Brenner and Andrew Philp and Gareth G. Lavery},
journal = {Cell Reports},
year = {2019},
doi = {10.1016/j.celrep.2019.07.043},
}
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