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NAD<sup>+</sup> augmentation in brain aging: hype, hope, or emerging reality?

Wang HL, Zhang J, Fang EF.

Trends in endocrinology and metabolism: TEM · 2026

Deregulated nutrient-sensing Human Preclinical / animal
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Abstract

Restoring NAD<sup>+</sup> to physiological levels shows promise for countering brain aging and neurodegeneration, backed by preclinical and growing clinical evidence. Key challenges remain: measurement validity, brain delivery, optimal dosing, and trial design. This forum examines current evidence, addresses ongoing controversies, and outlines priorities for future research and translation.

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Provenance

Source
Europe PMC
DOI
10.1016/j.tem.2026.09.003
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2026-10-09 MST

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APA
HL, W., J, Z., &amp; EF., F. (2026). NAD&lt;sup&gt;+&lt;/sup&gt; augmentation in brain aging: hype, hope, or emerging reality?. <em>Trends in endocrinology and metabolism: TEM</em>. https://doi.org/10.1016/j.tem.2026.09.003
Vancouver
HL W, J Z, EF. F. NAD&lt;sup&gt;+&lt;/sup&gt; augmentation in brain aging: hype, hope, or emerging reality?. Trends in endocrinology and metabolism: TEM. 2026. doi:10.1016/j.tem.2026.09.003.
BibTeX
@article{wang2026NADlts, title = {NAD&lt;sup&gt;+&lt;/sup&gt; augmentation in brain aging: hype, hope, or emerging reality?}, author = {Wang HL and Zhang J and Fang EF.}, journal = {Trends in endocrinology and metabolism: TEM}, year = {2026}, doi = {10.1016/j.tem.2026.09.003}, }

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