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Myc activates telomerase

Jing Wang, Lin Ying Xie, Susan Allan, David Beach, Gregory J. Hannon

Genes & Development · 1998 · ▲ 653 citations

Telomere attrition Cell culture / in vitro Human

Abstract

Telomere maintenance has been proposed as an essential prerequisite to human tumor development. The telomerase enzyme is itself a marker for tumor cells, but the genetic alterations that activate the enzyme during neoplastic transformation have remained a mystery. Here, we show that Myc induces telomerase in both normal human mammary epithelial cells (HMECs) and normal human diploid fibroblasts. Myc increases expression of hEST2 (hTRT/TP2), the limiting subunit of telomerase, and both Myc and hEST2 can extend the life span of HMECs. The ability of Myc to activate telomerase may contribute to its ability to promote tumor formation.

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Provenance

Source: OpenAlex
DOI: 10.1101/gad.12.12.1769
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Fetched: 2026-10-31 MST

Cite this

APA

Wang, J., Xie, L.Y., Allan, S., Beach, D., & Hannon, G.J. (1998). Myc activates telomerase. <em>Genes & Development</em>. https://doi.org/10.1101/gad.12.12.1769

Vancouver

Wang J, Xie LY, Allan S, Beach D, Hannon GJ. Myc activates telomerase. Genes & Development. 1998. doi:10.1101/gad.12.12.1769.

BibTeX

@unpublished{jing1998Mycact, title = {Myc activates telomerase}, author = {Jing Wang and Lin Ying Xie and Susan Allan and David Beach and Gregory J. Hannon}, journal = {Genes & Development}, year = {1998}, doi = {10.1101/gad.12.12.1769}, }