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Muscle function decline and mitochondria changes in middle age precede sarcopenia in mice

Andrea del Campo, Ignacio Contreras‐Hernandez, Mauricio Castro‐Sepúlveda, Cristian A. Campos, Reinaldo Figueroa, María Florencia Tevy, Verónica Eisner, Mariana Casas, Enrique Jaimovich

Aging · 2018 · ▲ 110 citations

Mitochondrial dysfunction Mouse

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Abstract

resting levels were reduced at age 10-14 months and significantly increased in the Older group. This was consistent with a reduced number of mitochondria-to-jSR pairs in the Older group compared to the Juvenile. Our results support the idea of several age-dependent changes in mitochondria that are accentuated in midlife prior to a complete sarcopenic phenotype.

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Provenance

Source: OpenAlex
DOI: 10.18632/aging.101358
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Fetched: 2026-10-17 MST

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APA

Campo, A.D., Contreras‐Hernandez, I., Castro‐Sepúlveda, M., Campos, C.A., Figueroa, R., Tevy, M.F., Eisner, V., Casas, M., & Jaimovich, E. (2018). Muscle function decline and mitochondria changes in middle age precede sarcopenia in mice. <em>Aging</em>. https://doi.org/10.18632/aging.101358

Vancouver

Campo AD, Contreras‐Hernandez I, Castro‐Sepúlveda M, Campos CA, Figueroa R, Tevy MF, et al. Muscle function decline and mitochondria changes in middle age precede sarcopenia in mice. Aging. 2018. doi:10.18632/aging.101358.

BibTeX

@unpublished{andrea2018Muscle, title = {Muscle function decline and mitochondria changes in middle age precede sarcopenia in mice}, author = {Andrea del Campo and Ignacio Contreras‐Hernandez and Mauricio Castro‐Sepúlveda and Cristian A. Campos and Reinaldo Figueroa and María Florencia Tevy and Verónica Eisner and Mariana Casas and Enrique Jaimovich}, journal = {Aging}, year = {2018}, doi = {10.18632/aging.101358}, }