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Multifactorial conceptual model of cancer-related accelerated aging.

Morse L, Weiss S, Ritchie CS, Wong ML, Hoffmann T, Wallhagen M, Miaskowski C.

npj aging · 2026

Epigenetic alterations Human Review

Abstract

Evidence suggests that cancer-related accelerated aging contributes to an earlier onset of chronic diseases; persistent symptoms; and decrements in patients' quality of life. This review presents the Multifactorial Model of Cancer-related Accelerated Aging (MMCRAA), a conceptual framework that is grounded in Life Course Theory and supported by empiric evidence. The model includes six inter-related concepts: person, behavioral, biological, treatment, symptom, and life course factors. The MMCRAA can be used by clinicians and researchers to identify patients at increased risk for cancer-related accelerated aging; guide personalized treatment planning; and inform the development of interventions and research.

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Provenance

Source: Europe PMC
DOI: 10.1038/s41514-025-00328-8
Canonical: link ↗
Fetched: 2026-07-01 MST

Cite this

APA

L, M., S, W., CS, R., ML, W., T, H., M, W., & C., M. (2026). Multifactorial conceptual model of cancer-related accelerated aging. <em>npj aging</em>. https://doi.org/10.1038/s41514-025-00328-8

Vancouver

L M, S W, CS R, ML W, T H, M W, et al. Multifactorial conceptual model of cancer-related accelerated aging. npj aging. 2026. doi:10.1038/s41514-025-00328-8.

BibTeX

@article{morse2026Multif, title = {Multifactorial conceptual model of cancer-related accelerated aging.}, author = {Morse L and Weiss S and Ritchie CS and Wong ML and Hoffmann T and Wallhagen M and Miaskowski C.}, journal = {npj aging}, year = {2026}, doi = {10.1038/s41514-025-00328-8}, }