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Multifactorial conceptual model of cancer-related accelerated aging

Morse Lh, S Weiss, Christine S. Ritchie, Melisa L. Wong, Thomas K. Hoffmann, Margaret Wallhagen, Christine Miaskowski

npj Aging · 2026

Epigenetic alterations Human Review

Abstract

Evidence suggests that cancer-related accelerated aging contributes to an earlier onset of chronic diseases; persistent symptoms; and decrements in patients' quality of life. This review presents the Multifactorial Model of Cancer-related Accelerated Aging (MMCRAA), a conceptual framework that is grounded in Life Course Theory and supported by empiric evidence. The model includes six inter-related concepts: person, behavioral, biological, treatment, symptom, and life course factors. The MMCRAA can be used by clinicians and researchers to identify patients at increased risk for cancer-related accelerated aging; guide personalized treatment planning; and inform the development of interventions and research.

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Provenance

Source: OpenAlex
DOI: 10.1038/s41514-025-00328-8
Canonical: link ↗
Fetched: 2026-06-10 MST

Cite this

APA

Lh, M., Weiss, S., Ritchie, C.S., Wong, M.L., Hoffmann, T.K., Wallhagen, M., & Miaskowski, C. (2026). Multifactorial conceptual model of cancer-related accelerated aging. <em>npj Aging</em>. https://doi.org/10.1038/s41514-025-00328-8

Vancouver

Lh M, Weiss S, Ritchie CS, Wong ML, Hoffmann TK, Wallhagen M, et al. Multifactorial conceptual model of cancer-related accelerated aging. npj Aging. 2026. doi:10.1038/s41514-025-00328-8.

BibTeX

@article{morse2026Multif, title = {Multifactorial conceptual model of cancer-related accelerated aging}, author = {Morse Lh and S Weiss and Christine S. Ritchie and Melisa L. Wong and Thomas K. Hoffmann and Margaret Wallhagen and Christine Miaskowski}, journal = {npj Aging}, year = {2026}, doi = {10.1038/s41514-025-00328-8}, }