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Molecule-dynamic-based Aging Clock and Aging Roadmap Forecast with Sundial

Wei Wu, Deng, Zizhen, Chi Zhang, Liao, Can, Wang, Jinzhuo

arXiv (Cornell University) · 2025

Loss of proteostasis

Abstract

Addressing the unavoidable bias inherent in supervised aging clocks, we introduce Sundial, a novel framework that models molecular dynamics through a diffusion field, capturing both the population-level aging process and the individual-level relative aging order. Sundial enables unbiasedestimation of biological age and the forecast of aging roadmap. Fasteraging individuals from Sundial exhibit a higher disease risk compared to those identified from supervised aging clocks. This framework opens new avenues for exploring key topics, including age- and sex-specific aging dynamics and faster yet healthy aging paths.

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Provenance

Source: OpenAlex
DOI: 10.48550/arxiv.2501.02176
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Fetched: 2026-10-14 MST

Cite this

APA

Wu, W., Zizhen, D., Zhang, C., Can, L., & Jinzhuo, W. (2025). Molecule-dynamic-based Aging Clock and Aging Roadmap Forecast with Sundial. <em>arXiv (Cornell University)</em>. https://doi.org/10.48550/arxiv.2501.02176

Vancouver

Wu W, Zizhen D, Zhang C, Can L, Jinzhuo W. Molecule-dynamic-based Aging Clock and Aging Roadmap Forecast with Sundial. arXiv (Cornell University). 2025. doi:10.48550/arxiv.2501.02176.

BibTeX

@unpublished{wei2025Molecu, title = {Molecule-dynamic-based Aging Clock and Aging Roadmap Forecast with Sundial}, author = {Wei Wu and Deng, Zizhen and Chi Zhang and Liao, Can and Wang, Jinzhuo}, journal = {arXiv (Cornell University)}, year = {2025}, doi = {10.48550/arxiv.2501.02176}, }