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Mitochondrial dysfunction in aging: Much progress but many unresolved questions

Brendan A. I. Payne, Patrick Francis Chinnery

Biochimica et Biophysica Acta (BBA) - Bioenergetics · 2015 · ▲ 346 citations

Mitochondrial dysfunction

Abstract

The free radical theory of aging is almost 60 years old. As mitochondria are the principle source of intracellular reactive oxygen species (ROS), this hypothesis suggested a central role for the mitochondrion in normal mammalian aging. In recent years, however, much work has questioned the importance of mitochondrial ROS in driving aging. Conversely new evidence points to other facets of mitochondrial dysfunction which may nevertheless suggest the mitochondrion retains a critical role at the center of a complex web of processes leading to cellular and organismal aging.

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Provenance

Source: OpenAlex
DOI: 10.1016/j.bbabio.2015.05.022
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Fetched: 2026-10-03 MST

Cite this

APA

Payne, B.A.I., & Chinnery, P.F. (2015). Mitochondrial dysfunction in aging: Much progress but many unresolved questions. <em>Biochimica et Biophysica Acta (BBA) - Bioenergetics</em>. https://doi.org/10.1016/j.bbabio.2015.05.022

Vancouver

Payne BAI, Chinnery PF. Mitochondrial dysfunction in aging: Much progress but many unresolved questions. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 2015. doi:10.1016/j.bbabio.2015.05.022.

BibTeX

@article{brendan2015Mitoch, title = {Mitochondrial dysfunction in aging: Much progress but many unresolved questions}, author = {Brendan A. I. Payne and Patrick Francis Chinnery}, journal = {Biochimica et Biophysica Acta (BBA) - Bioenergetics}, year = {2015}, doi = {10.1016/j.bbabio.2015.05.022}, }