Open access · OA via OpenAlex

Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation.

Catherine M Kolf, Elizabeth Cho, Rocky S. Tuan

Arthritis Research & Therapy · 2007 · ▲ 909 citations

Stem-cell exhaustion Altered intercellular communication Stem-cell therapy Human Review

Abstract

Recent advances in understanding the cellular and molecular signaling pathways and global transcriptional regulators of adult mesenchymal stem cells have provided new insights into their biology and potential clinical applications, particularly for tissue repair and regeneration. This review focuses on these advances, specifically in the context of self-renewal and regulation of lineage-specific differentiation of mesenchymal stem cells. In addition we review recent research on the concept of stem cell niche, and its relevance to adult mesenchymal stem cells.

◌ CITATION ONLY
Full text is not openly licensed for redistribution here. Read it at the source:

Read at source →

Provenance

Source: OpenAlex
DOI: 10.1186/ar2116
Canonical: link ↗
Fetched: 2026-06-19 MST

Cite this

APA

Kolf, C.M., Cho, E., & Tuan, R.S. (2007). Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation. <em>Arthritis Research & Therapy</em>. https://doi.org/10.1186/ar2116

Vancouver

Kolf CM, Cho E, Tuan RS. Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation. Arthritis Research & Therapy. 2007. doi:10.1186/ar2116.

BibTeX

@article{catherine2007Mesenc, title = {Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation.}, author = {Catherine M Kolf and Elizabeth Cho and Rocky S. Tuan}, journal = {Arthritis Research & Therapy}, year = {2007}, doi = {10.1186/ar2116}, }