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Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?

Meng Kou, Li Huang, Jinjuan Yang, Zhixin Chiang, Shaoxiang Chen, Jie Liu, Liyan Guo, Xiaoxian Zhang, Xiaoya Zhou, Xiang Xu, Xiaomei Yan, Yan Wang, Jinqiu Zhang, Aimin Xu, Hung‐Fat Tse

Cell Death and Disease · 2022 · ▲ 575 citations

Stem-cell exhaustion Altered intercellular communication Stem-cell therapy Human

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Abstract

Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and multipotent differentiation. There is compelling evidence that the therapeutic effect of MSCs mainly depends on their paracrine action. Extracellular vesicles (EVs) are fundamental paracrine effectors of MSCs and play a crucial role in intercellular communication, existing in various body fluids and cell supernatants. Since MSC-derived EVs retain the function of protocells and have lower immunogenicity, they have a wide range of prospective therapeutic applications with advantages over cell therapy. We describe some characteristics of MSC-EVs, and discuss their role in immune regulation and regeneration, with emphasis on the molecular mechanism and application of MSC-EVs in the treatment of fibrosis and support tissue repair. We also highlight current challenges in the clinical application of MSC-EVs and potential ways to overcome the problem of quality heterogeneity.

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Provenance

Source: OpenAlex
DOI: 10.1038/s41419-022-05034-x
Canonical: link ↗
Fetched: 2026-06-13 MST

Cite this

APA

Kou, M., Huang, L., Yang, J., Chiang, Z., Chen, S., Liu, J., Guo, L., Zhang, X., Zhou, X., Xu, X., Yan, X., Wang, Y., Zhang, J., Xu, A., Tse, H., & Lian, Q. (2022). Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?. <em>Cell Death and Disease</em>. https://doi.org/10.1038/s41419-022-05034-x

Vancouver

Kou M, Huang L, Yang J, Chiang Z, Chen S, Liu J, et al. Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?. Cell Death and Disease. 2022. doi:10.1038/s41419-022-05034-x.

BibTeX

@article{meng2022Mesenc, title = {Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?}, author = {Meng Kou and Li Huang and Jinjuan Yang and Zhixin Chiang and Shaoxiang Chen and Jie Liu and Liyan Guo and Xiaoxian Zhang and Xiaoya Zhou and Xiang Xu and Xiaomei Yan and Yan Wang and Jinqiu Zhang and Aimin Xu and Hung‐Fat Tse and Qizhou Lian}, journal = {Cell Death and Disease}, year = {2022}, doi = {10.1038/s41419-022-05034-x}, }