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MAGHEMITE PARTICLES FOR SPERMIDINE SEPARATION

Pavel Kopel, Natalia Cernei, Pavel Horký, Zuzana Lacková, Vedran Milosavljević, Milica Gagić, Ondřej Zítka, Vojtěch Adam

NANOCOM ... · 2020

Altered intercellular communication Spermidine Human

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Abstract

We report the optimal conditions for the separation of spermidine from different types of samples, for example blood or cancer cells and its subsequent determination by ion-exchange liquid chromatography (IEC) with UV-VIS detector.Here in, we synthesized paramagnetic particles able to isolate and immobilize spermidine from blood of patients with cancer or cancer cells and thus preconcentrate it for analysis.Dowex surface was covered by nanomaghemite (γ-Fe2O3) or maghemite particles surface was modified by chitosan and sulfoxyethyl cellulose.The best separation properties showed Dowex microparticles.The paramagnetic particles can be used in the future for isolation of spermidine from real samples and diagnosis of cancer.

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Provenance

Source: OpenAlex
DOI: 10.37904/nanocon.2019.8496
Canonical: link ↗
Fetched: 2026-10-09 MST

Cite this

APA

Kopel, P., Cernei, N., Horký, P., Lacková, Z., Milosavljević, V., Gagić, M., Zítka, O., & Adam, V. (2020). MAGHEMITE PARTICLES FOR SPERMIDINE SEPARATION. <em>NANOCOM ...</em>. https://doi.org/10.37904/nanocon.2019.8496

Vancouver

Kopel P, Cernei N, Horký P, Lacková Z, Milosavljević V, Gagić M, et al. MAGHEMITE PARTICLES FOR SPERMIDINE SEPARATION. NANOCOM .... 2020. doi:10.37904/nanocon.2019.8496.

BibTeX

@article{pavel2020MAGHEM, title = {MAGHEMITE PARTICLES FOR SPERMIDINE SEPARATION}, author = {Pavel Kopel and Natalia Cernei and Pavel Horký and Zuzana Lacková and Vedran Milosavljević and Milica Gagić and Ondřej Zítka and Vojtěch Adam}, journal = {NANOCOM ...}, year = {2020}, doi = {10.37904/nanocon.2019.8496}, }