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Longevity factor klotho enhances cognition in aged nonhuman primates

Stacy A. Castner, Shweta Gupta, Dan Wang, Arturo J. Moreno, Cana Park, Chen Chen, Yan Poon, Aaron Chris Groen, Kenneth Greenberg, Nathaniel E. David, T. Boone, Mark G. Baxter, Graham V. Williams, Dena B. Dubal

Nature Aging · 2023 · ▲ 114 citations

Epigenetic alterations Non-human primate Human Mouse

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Abstract

Cognitive dysfunction in aging is a major biomedical challenge. Whether treatment with klotho, a longevity factor, could enhance cognition in human-relevant models such as in nonhuman primates is unknown and represents a major knowledge gap in the path to therapeutics. We validated the rhesus form of the klotho protein in mice showing it increased synaptic plasticity and cognition. We then found that a single administration of low-dose, but not high-dose, klotho enhanced memory in aged nonhuman primates. Systemic low-dose klotho treatment may prove therapeutic in aging humans.

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Provenance

Source: OpenAlex
DOI: 10.1038/s43587-023-00441-x
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Fetched: 2026-10-26 MST

Cite this

APA

Castner, S.A., Gupta, S., Wang, D., Moreno, A.J., Park, C., Chen, C., Poon, Y., Groen, A.C., Greenberg, K., David, N.E., Boone, T., Baxter, M.G., Williams, G.V., & Dubal, D.B. (2023). Longevity factor klotho enhances cognition in aged nonhuman primates. <em>Nature Aging</em>. https://doi.org/10.1038/s43587-023-00441-x

Vancouver

Castner SA, Gupta S, Wang D, Moreno AJ, Park C, Chen C, et al. Longevity factor klotho enhances cognition in aged nonhuman primates. Nature Aging. 2023. doi:10.1038/s43587-023-00441-x.

BibTeX

@article{stacy2023Longev, title = {Longevity factor klotho enhances cognition in aged nonhuman primates}, author = {Stacy A. Castner and Shweta Gupta and Dan Wang and Arturo J. Moreno and Cana Park and Chen Chen and Yan Poon and Aaron Chris Groen and Kenneth Greenberg and Nathaniel E. David and T. Boone and Mark G. Baxter and Graham V. Williams and Dena B. Dubal}, journal = {Nature Aging}, year = {2023}, doi = {10.1038/s43587-023-00441-x}, }