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Long non-coding RNAs and accelerated aging in bipolar disorder.

Ekinci S, Arat Çelik HE, Fettahoğlu İ, Squassina A, Ceylan D.

Neuroscience applied · 2026

Telomere attrition Epigenetic alterations Review

Abstract

Bipolar disorder (BD) has been associated with accelerated biological aging, potentially driven by genetic and environmental factors. Long non-coding RNAs (lncRNAs), key regulators of epigenetic, telomere attrition, and cellular aging processes, may play a role in accelerated aging in BD. This review summarizes current evidence on aging-associated lncRNAs and their relevance to BD. We searched PubMed for English-language original studies published up to June 2, 2025, using keywords related to lncRNAs, aging-related mechanisms, and aging-associated neuropsychiatric disorders. A total of 112 articles reported 163 lncRNAs, of which 19 were common to aging-related mechanisms and aging-associated neuropsychiatric disorders. Among these, ANRIL, HOTAIR, TUG1, MALAT1, NEAT1, and GAS5 have been reported in both aging-related contexts and BD; however, their relevance to BD requires further confirmation in independent and well-characterized cohorts. The remaining overlapping lncRNAs may represent additional candidates of interest for future investigation rather than established contributors to BD pathophysiology.

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Provenance

Source: Europe PMC
DOI: 10.1016/j.nsa.2026.106990
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Fetched: 2026-07-01 MST

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APA

S, E., HE, A.�., İ, F., A, S., & D., C. (2026). Long non-coding RNAs and accelerated aging in bipolar disorder. <em>Neuroscience applied</em>. https://doi.org/10.1016/j.nsa.2026.106990

Vancouver

S E, HE A�, İ F, A S, D. C. Long non-coding RNAs and accelerated aging in bipolar disorder. Neuroscience applied. 2026. doi:10.1016/j.nsa.2026.106990.

BibTeX

@article{ekinci2026Longno, title = {Long non-coding RNAs and accelerated aging in bipolar disorder.}, author = {Ekinci S and Arat Çelik HE and Fettahoğlu İ and Squassina A and Ceylan D.}, journal = {Neuroscience applied}, year = {2026}, doi = {10.1016/j.nsa.2026.106990}, }