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Kinetics and biomarkers of severe cytokine release syndrome after CD19 chimeric antigen receptor–modified T-cell therapy

Kevin A. Hay, Laïla‐Aïcha Hanafi, Daniel Li, Juliane Gust, W. Conrad Liles, Mark M. Wurfel, José A. López, Junmei Chen, Dominic W. Chung, Susanna Harju-Baker, Sindhu Cherian, Xueyan Chen, Stanley R. Riddell, David G. Maloney, Cameron J. Turtle

Blood · 2017 · ▲ 1,126 citations

Chronic inflammation Human

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Abstract

central memory T cells as independent predictors of CRS. Severe CRS was characterized by hemodynamic instability, capillary leak, and consumptive coagulopathy. Angiopoietin-2 and von Willebrand factor, which are biomarkers of endothelial activation, were increased during severe CRS and also before lymphodepletion in patients who subsequently developed CRS. We describe a classification-tree algorithm to guide studies of early intervention after CAR T-cell infusion for patients at high risk of severe CRS. These data provide a framework for early intervention studies to facilitate safer application of effective CD19 CAR T-cell therapy.

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Provenance

Source: OpenAlex
DOI: 10.1182/blood-2017-06-793141
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Fetched: 2026-07-28 MST

Cite this

APA

Hay, K.A., Hanafi, L., Li, D., Gust, J., Liles, W.C., Wurfel, M.M., López, J.A., Chen, J., Chung, D.W., Harju-Baker, S., Cherian, S., Chen, X., Riddell, S.R., Maloney, D.G., & Turtle, C.J. (2017). Kinetics and biomarkers of severe cytokine release syndrome after CD19 chimeric antigen receptor–modified T-cell therapy. <em>Blood</em>. https://doi.org/10.1182/blood-2017-06-793141

Vancouver

Hay KA, Hanafi L, Li D, Gust J, Liles WC, Wurfel MM, et al. Kinetics and biomarkers of severe cytokine release syndrome after CD19 chimeric antigen receptor–modified T-cell therapy. Blood. 2017. doi:10.1182/blood-2017-06-793141.

BibTeX

@article{kevin2017Kineti, title = {Kinetics and biomarkers of severe cytokine release syndrome after CD19 chimeric antigen receptor–modified T-cell therapy}, author = {Kevin A. Hay and Laïla‐Aïcha Hanafi and Daniel Li and Juliane Gust and W. Conrad Liles and Mark M. Wurfel and José A. López and Junmei Chen and Dominic W. Chung and Susanna Harju-Baker and Sindhu Cherian and Xueyan Chen and Stanley R. Riddell and David G. Maloney and Cameron J. Turtle}, journal = {Blood}, year = {2017}, doi = {10.1182/blood-2017-06-793141}, }