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Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential

Christian M. Nefzger, Thierry Jardé, Akanksha Srivastava, Jan Schröder, Fernando J. Rossello, Katja Horvay, Mirsada Prasko, Jacob M. Paynter, Joseph Chen, Chen-Fang Weng, Yu Sun, Xiaodong Liu, Eva L. Chan, Nikita Deshpande, Xiaoli Chen

npj Regenerative Medicine · 2022 · ▲ 20 citations

Epigenetic alterations Stem-cell exhaustion Partial reprogramming (OSK)

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Abstract

The impact of aging on intestinal stem cells (ISCs) has not been fully elucidated. In this study, we identified widespread epigenetic and transcriptional alterations in old ISCs. Using a reprogramming algorithm, we identified a set of key transcription factors (Egr1, Irf1, FosB) that drives molecular and functional differences between old and young states. Overall, by dissecting the molecular signature of aged ISCs, our study identified transcription factors that enhance the regenerative capacity of ISCs.

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Provenance

Source: OpenAlex
DOI: 10.1038/s41536-022-00226-7
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Fetched: 2026-06-18 MST

Cite this

APA

Nefzger, C.M., Jardé, T., Srivastava, A., Schröder, J., Rossello, F.J., Horvay, K., Prasko, M., Paynter, J.M., Chen, J., Weng, C., Sun, Y., Liu, X., Chan, E.L., Deshpande, N., Chen, X., Li, Y.J., Pflueger, J., Engel, R., Knaupp, A.S., & Tsyganov, K. (2022). Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential. <em>npj Regenerative Medicine</em>. https://doi.org/10.1038/s41536-022-00226-7

Vancouver

Nefzger CM, Jardé T, Srivastava A, Schröder J, Rossello FJ, Horvay K, et al. Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential. npj Regenerative Medicine. 2022. doi:10.1038/s41536-022-00226-7.

BibTeX

@article{christian2022Intest, title = {Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential}, author = {Christian M. Nefzger and Thierry Jardé and Akanksha Srivastava and Jan Schröder and Fernando J. Rossello and Katja Horvay and Mirsada Prasko and Jacob M. Paynter and Joseph Chen and Chen-Fang Weng and Yu Sun and Xiaodong Liu and Eva L. Chan and Nikita Deshpande and Xiaoli Chen and Y. Jinhua Li and Jahnvi Pflueger and Rebekah Engel and Anja S. Knaupp and Kirill Tsyganov and Susan K. Nilsson and Ryan Lister and Owen J. L. Rackham and Helen E. Abud and José M. Polo}, journal = {npj Regenerative Medicine}, year = {2022}, doi = {10.1038/s41536-022-00226-7}, }