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Interventions for age-related diseases: Shifting the paradigm

Inês Figueira, Adelaide Fernandes, Aleksandra Mladenović, Andrés J. López‐Contreras, Catarina M. Henriques, Colin Selman, Elisabete Ferreiro, Efstathios S. Gonos, José Luís Trejo, Juhi Misra, Lene Juel Rasmussen, Sara Xapelli, Timothy Ellam, Ilaria Bellantuono

Mechanisms of Ageing and Development · 2016 · ▲ 95 citations

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Abstract

Over 60% of people aged over 65 are affected by multiple morbidities, which are more difficult to treat, generate increased healthcare costs and lead to poor quality of life compared to individual diseases. With the number of older people steadily increasing this presents a societal challenge. Age is the major risk factor for age-related diseases and recent research developments have led to the proposal that pharmacological interventions targeting common mechanisms of ageing may be able to delay the onset of multimorbidity. Here we review the state of the knowledge of multimorbidity, appraise the available evidence supporting the role of mechanisms of ageing in the development of the most common age-related diseases and assess potential molecules that may successfully target those key mechanisms.

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Provenance

Source: OpenAlex
DOI: 10.1016/j.mad.2016.09.009
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Fetched: 2026-06-14 MST

Cite this

APA

Figueira, I., Fernandes, A., Mladenović, A., López‐Contreras, A.J., Henriques, C.M., Selman, C., Ferreiro, E., Gonos, E.S., Trejo, J.L., Misra, J., Rasmussen, L.J., Xapelli, S., Ellam, T., & Bellantuono, I. (2016). Interventions for age-related diseases: Shifting the paradigm. <em>Mechanisms of Ageing and Development</em>. https://doi.org/10.1016/j.mad.2016.09.009

Vancouver

Figueira I, Fernandes A, Mladenović A, López‐Contreras AJ, Henriques CM, Selman C, et al. Interventions for age-related diseases: Shifting the paradigm. Mechanisms of Ageing and Development. 2016. doi:10.1016/j.mad.2016.09.009.

BibTeX

@article{ins2016Interv, title = {Interventions for age-related diseases: Shifting the paradigm}, author = {Inês Figueira and Adelaide Fernandes and Aleksandra Mladenović and Andrés J. López‐Contreras and Catarina M. Henriques and Colin Selman and Elisabete Ferreiro and Efstathios S. Gonos and José Luís Trejo and Juhi Misra and Lene Juel Rasmussen and Sara Xapelli and Timothy Ellam and Ilaria Bellantuono}, journal = {Mechanisms of Ageing and Development}, year = {2016}, doi = {10.1016/j.mad.2016.09.009}, }