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Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains

Christian Haenig, Nir Atias, Alexander K. Taylor, Arnon Mazza, Martin H. Schaefer, Jenny Russ, Sean‐Patrick Riechers, Shushant Jain, Maura Coughlin, Jean−Fred Fontaine, Brian D. Freibaum, Lydia Brusendorf, Martina Zenkner, Pablo Porras, Martin Stroedicke

Cell Reports · 2020 · ▲ 119 citations

Abstract

that controls misfolding and aggregation of multiple ND-causing proteins in experimental model systems. Furthermore, it enables the prediction of ND-specific subnetworks and the identification of proteins, such as ATXN1 and MKL1, that are abnormally aggregated in postmortem brains of Alzheimer's disease patients, suggesting widespread protein aggregation in NDs.

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OpenAlex
DOI
10.1016/j.celrep.2020.108050
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2026-06-14 MST

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APA
Haenig, C., Atias, N., Taylor, A.K., Mazza, A., Schaefer, M.H., Russ, J., Riechers, S., Jain, S., Coughlin, M., Fontaine, J., Freibaum, B.D., Brusendorf, L., Zenkner, M., Porras, P., Stroedicke, M., Schnoegl, S., Arnsburg, K., Boeddrich, A., Pigazzini, L., &amp; Heutink, P. (2020). Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. <em>Cell Reports</em>. https://doi.org/10.1016/j.celrep.2020.108050
Vancouver
Haenig C, Atias N, Taylor AK, Mazza A, Schaefer MH, Russ J, et al. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. Cell Reports. 2020. doi:10.1016/j.celrep.2020.108050.
BibTeX
@article{christian2020Intera, title = {Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains}, author = {Christian Haenig and Nir Atias and Alexander K. Taylor and Arnon Mazza and Martin H. Schaefer and Jenny Russ and Sean‐Patrick Riechers and Shushant Jain and Maura Coughlin and Jean−Fred Fontaine and Brian D. Freibaum and Lydia Brusendorf and Martina Zenkner and Pablo Porras and Martin Stroedicke and Sigrid Schnoegl and Kristin Arnsburg and Annett Boeddrich and Lucia Pigazzini and Peter Heutink and J. Paul Taylor and Janine Kirstein and Miguel A. Andrade‐Navarro and Roded Sharan and Erich E. Wanker}, journal = {Cell Reports}, year = {2020}, doi = {10.1016/j.celrep.2020.108050}, }

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