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Interaction of α‐synuclein and tau genotypes in Parkinson's disease

Catherine Mamah, Timothy G. Lesnick, Sarah Lincoln, Kari J. Strain, Mariza de Andrade, James H. Bower, J. Eric Ahlskog, Walter A. Rocca, Matthew James Farrer, Demetrius M. Maraganore

Annals of Neurology · 2005 · ▲ 47 citations

Loss of proteostasis Cell culture / in vitro In vitro

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Abstract

To determine whether the microtubule-associated protein tau (MAPT) and alpha-synuclein (SNCA) genes interact to confer Parkinson's disease (PD) susceptibility, we conducted a study of 557 case-control pairs. There was an increased risk of PD for persons with either SNCA 261/261 or MAPT H1/H1 genotypes as compared with persons with neither (odds ratio, 1.96; 95% confidence interval, 1.34-2.86; p = 0.0003). However, the combined effect of the two genotypes was the same as for either of the genotypes alone (separate and equal). These findings are consistent with in vitro experiments that revealed tau-mediated fibrillization of alpha-synuclein protein at low concentrations (dose threshold effect).

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Provenance

Source: OpenAlex
DOI: 10.1002/ana.20387
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Fetched: 2026-10-21 MST

Cite this

APA

Mamah, C., Lesnick, T.G., Lincoln, S., Strain, K.J., Andrade, M.D., Bower, J.H., Ahlskog, J.E., Rocca, W.A., Farrer, M.J., & Maraganore, D.M. (2005). Interaction of α‐synuclein and tau genotypes in Parkinson's disease. <em>Annals of Neurology</em>. https://doi.org/10.1002/ana.20387

Vancouver

Mamah C, Lesnick TG, Lincoln S, Strain KJ, Andrade MD, Bower JH, et al. Interaction of α‐synuclein and tau genotypes in Parkinson's disease. Annals of Neurology. 2005. doi:10.1002/ana.20387.

BibTeX

@article{catherine2005Intera, title = {Interaction of α‐synuclein and tau genotypes in Parkinson's disease}, author = {Catherine Mamah and Timothy G. Lesnick and Sarah Lincoln and Kari J. Strain and Mariza de Andrade and James H. Bower and J. Eric Ahlskog and Walter A. Rocca and Matthew James Farrer and Demetrius M. Maraganore}, journal = {Annals of Neurology}, year = {2005}, doi = {10.1002/ana.20387}, }