Inhibition of neuronal autophagy mediates longevity

Aging describes the age-dependent decline in the physiological functions of an organism, which affects fitness and predisposes for age-related diseases.A prominent feature of aging is the impairment of cellular homeostasis, which contributes to the emergence of neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington's disease [1].One critical process that maintains cellular metabolism and homeostasis is macroautophagy (referred here to as autophagy(definition)).This highly conserved bulk degradation program engulfs dysfunctional organelles and misfolded proteins by double membrane structures to form autophagosomes.The subsequent fusion of autophago-