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Implications of Genetic and Epigenetic Alterations of CDKN2A (p16 INK4a ) in Cancer

Ran Zhao, Bu Young Choi, Mee-Hyun Lee, Ann M. Bode, Zigang Dong

EBioMedicine · 2016 · ▲ 431 citations

Epigenetic alterations Cellular senescence Review

Abstract

Aberrant gene silencing is highly associated with altered cell cycle regulation during carcinogenesis. In particular, silencing of the CDKN2A tumor suppressor gene, which encodes the p16(INK4a) protein, has a causal link with several different types of cancers. The p16(INK4a) protein plays an executional role in cell cycle and senescence through the regulation of the cyclin-dependent kinase (CDK) 4/6 and cyclin D complexes. Several genetic and epigenetic aberrations of CDKN2A lead to enhanced tumorigenesis and metastasis with recurrence of cancer and poor prognosis. In these cases, the restoration of genetic and epigenetic reactivation of CDKN2A is a practical approach for the prevention and therapy of cancer. This review highlights the genetic status of CDKN2A as a prognostic and predictive biomarker in various cancers.

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Provenance

Source: OpenAlex
DOI: 10.1016/j.ebiom.2016.04.017
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Fetched: 2026-06-09 MST

Cite this

APA

Zhao, R., Choi, B.Y., Lee, M., Bode, A.M., & Dong, Z. (2016). Implications of Genetic and Epigenetic Alterations of CDKN2A (p16 INK4a ) in Cancer. <em>EBioMedicine</em>. https://doi.org/10.1016/j.ebiom.2016.04.017

Vancouver

Zhao R, Choi BY, Lee M, Bode AM, Dong Z. Implications of Genetic and Epigenetic Alterations of CDKN2A (p16 INK4a ) in Cancer. EBioMedicine. 2016. doi:10.1016/j.ebiom.2016.04.017.

BibTeX

@article{ran2016Implic, title = {Implications of Genetic and Epigenetic Alterations of CDKN2A (p16 INK4a ) in Cancer}, author = {Ran Zhao and Bu Young Choi and Mee-Hyun Lee and Ann M. Bode and Zigang Dong}, journal = {EBioMedicine}, year = {2016}, doi = {10.1016/j.ebiom.2016.04.017}, }