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IL-1β/IL-6/CRP and IL-18/ferritin: Distinct Inflammatory Programs in Infections

Jeroen Slaats, Jaap ten Oever, Frank L. van de Veerdonk, Mihai G. Netea

PLoS Pathogens · 2016 · ▲ 312 citations

Chronic inflammation Review

Abstract

The host inflammatory response against infections is characterized by the release of pro-inflammatory cytokines and acute-phase proteins, driving both innate and adaptive arms of the immune response. Distinct patterns of circulating cytokines and acute-phase responses have proven indispensable for guiding the diagnosis and management of infectious diseases. This review discusses the profiles of acute-phase proteins and circulating cytokines encountered in viral and bacterial infections. We also propose a model in which the inflammatory response to viral (IL-18/ferritin) and bacterial (IL-6/CRP) infections presents with specific plasma patterns of immune biomarkers.

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Provenance

Source: OpenAlex
DOI: 10.1371/journal.ppat.1005973
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Fetched: 2026-07-28 MST

Cite this

APA

Slaats, J., Oever, J.T., Veerdonk, F.L.V.D., & Netea, M.G. (2016). IL-1β/IL-6/CRP and IL-18/ferritin: Distinct Inflammatory Programs in Infections. <em>PLoS Pathogens</em>. https://doi.org/10.1371/journal.ppat.1005973

Vancouver

Slaats J, Oever JT, Veerdonk FLVD, Netea MG. IL-1β/IL-6/CRP and IL-18/ferritin: Distinct Inflammatory Programs in Infections. PLoS Pathogens. 2016. doi:10.1371/journal.ppat.1005973.

BibTeX

@article{jeroen2016ILILCR, title = {IL-1β/IL-6/CRP and IL-18/ferritin: Distinct Inflammatory Programs in Infections}, author = {Jeroen Slaats and Jaap ten Oever and Frank L. van de Veerdonk and Mihai G. Netea}, journal = {PLoS Pathogens}, year = {2016}, doi = {10.1371/journal.ppat.1005973}, }