Citation only via OpenAlex

Identification of Tri‐ and Tetracyclic Pyrimidinediones as Sirtuin Inhibitors

Dante Rotili, Domenico Tarantino, Vincenzo Carafa, Ester Lara, Sarah Meade, Giorgia Botta, Angela Nebbioso, Jörg Schemies, Manfred Jung, Aleksey G. Kazantsev, Manel Esteller, Mario F. Fraga, Lucia Altucci, Antonello Mai

ChemMedChem · 2010 · ▲ 48 citations

Deregulated nutrient-sensing

＋ Sign in to save

Abstract

Sirtuins are deacetylase proteins that regulate transcription, genome maintenance, longevity, and metabolism. Eight compounds were identified as a novel class of sirtuin inhibitors, with 5, 7, and 9 being the most effective as SIRT1-selective inhibitors. In U937 cells 5 induced apoptosis and displayed antiproliferative effects in Raji, DLD1, and HeLa cancer cells, suggesting potential utility in cancer treatment.

◌ CITATION ONLY
Full text is not openly licensed for redistribution here. Read it at the source:

Read at source →

Provenance

Source: OpenAlex
DOI: 10.1002/cmdc.201000030
Canonical: link ↗
Fetched: 2026-10-23 MST

Cite this

APA

Rotili, D., Tarantino, D., Carafa, V., Lara, E., Meade, S., Botta, G., Nebbioso, A., Schemies, J., Jung, M., Kazantsev, A.G., Esteller, M., Fraga, M.F., Altucci, L., & Mai, A. (2010). Identification of Tri‐ and Tetracyclic Pyrimidinediones as Sirtuin Inhibitors. <em>ChemMedChem</em>. https://doi.org/10.1002/cmdc.201000030

Vancouver

Rotili D, Tarantino D, Carafa V, Lara E, Meade S, Botta G, et al. Identification of Tri‐ and Tetracyclic Pyrimidinediones as Sirtuin Inhibitors. ChemMedChem. 2010. doi:10.1002/cmdc.201000030.

BibTeX

@article{dante2010Identi, title = {Identification of Tri‐ and Tetracyclic Pyrimidinediones as Sirtuin Inhibitors}, author = {Dante Rotili and Domenico Tarantino and Vincenzo Carafa and Ester Lara and Sarah Meade and Giorgia Botta and Angela Nebbioso and Jörg Schemies and Manfred Jung and Aleksey G. Kazantsev and Manel Esteller and Mario F. Fraga and Lucia Altucci and Antonello Mai}, journal = {ChemMedChem}, year = {2010}, doi = {10.1002/cmdc.201000030}, }