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Identification and replication of novel genetic variants of ABO gene to reduce the incidence of diseases and promote longevity by modulating lipid homeostasis

Xiaolin Ni, Chen Bai, Chao Nie, Liping Qi, Yifang Liu, Huiping Yuan, Xiaoquan Zhu, Liang Sun, Qi Zhou, Yan Li, Hefu Zhen, Huabing Su, Rongqiao Li, Rushu Lan, Guofang Pang

Aging · 2021 · ▲ 6 citations

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Abstract

= 1.530-1.997). Finally, two pathways involving vWF/ADAMTS13 and the inflammatory markers (sE-selectin/ICAM1) that co-regulated lipid levels by glycosylation and effects on each other were speculated. In conclusion, the association between the identified longevity-associated ABO variants and better health lipid profile was elucidated, thus the findings can help in maintaining normal lipid metabolic phenotypes in the longevity population.

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Provenance

Source: OpenAlex
DOI: 10.18632/aging.203700
Canonical: link ↗
Fetched: 2026-10-23 MST

Cite this

APA

Ni, X., Bai, C., Nie, C., Qi, L., Liu, Y., Yuan, H., Zhu, X., Sun, L., Zhou, Q., Li, Y., Zhen, H., Su, H., Li, R., Lan, R., Pang, G., Lv, Y., Zhang, W., Yang, F., Yao, Y., & Chen, C. (2021). Identification and replication of novel genetic variants of ABO gene to reduce the incidence of diseases and promote longevity by modulating lipid homeostasis. <em>Aging</em>. https://doi.org/10.18632/aging.203700

Vancouver

Ni X, Bai C, Nie C, Qi L, Liu Y, Yuan H, et al. Identification and replication of novel genetic variants of ABO gene to reduce the incidence of diseases and promote longevity by modulating lipid homeostasis. Aging. 2021. doi:10.18632/aging.203700.

BibTeX

@article{xiaolin2021Identi, title = {Identification and replication of novel genetic variants of ABO gene to reduce the incidence of diseases and promote longevity by modulating lipid homeostasis}, author = {Xiaolin Ni and Chen Bai and Chao Nie and Liping Qi and Yifang Liu and Huiping Yuan and Xiaoquan Zhu and Liang Sun and Qi Zhou and Yan Li and Hefu Zhen and Huabing Su and Rongqiao Li and Rushu Lan and Guofang Pang and Yuan Lv and Wei Zhang and Fan Yang and Yao Yao and Chen Chen and Zhaoping Wang and Danni Gao and Nan Zhang and Shenqi Zhang and Li Zhang}, journal = {Aging}, year = {2021}, doi = {10.18632/aging.203700}, }