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Hematopoietic stem cell transplantation

Eleftheria ChR. Hatzimichael, Mark H. Tuthill

Stem Cells and Cloning Advances and Applications · 2010 · ▲ 134 citations

Stem-cell exhaustion Stem-cell therapy Human Review

Abstract

More than 25,000 hematopoietic stem cell transplantations (HSCTs) are performed each year for the treatment of lymphoma, leukemia, immune-deficiency illnesses, congenital metabolic defects, hemoglobinopathies, and myelodysplastic and myeloproliferative syndromes. Before transplantation, patients receive intensive myeloablative chemoradiotherapy followed by stem cell "rescue." Autologous HSCT is performed using the patient's own hematopoietic stem cells, which are harvested before transplantation and reinfused after myeloablation. Allogeneic HSCT uses human leukocyte antigen (HLA)-matched stem cells derived from a donor. Survival after allogeneic transplantation depends on donor-recipient matching, the graft-versus-host response, and the development of a graft versus leukemia effect. This article reviews the biology of stem cells, clinical efficacy of HSCT, transplantation procedures, and potential complications.

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Provenance

Source: OpenAlex
DOI: 10.2147/sccaa.s6815
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Fetched: 2026-10-01 MST

Cite this

APA

Hatzimichael, E.C., & Tuthill, M.H. (2010). Hematopoietic stem cell transplantation. <em>Stem Cells and Cloning Advances and Applications</em>. https://doi.org/10.2147/sccaa.s6815

Vancouver

Hatzimichael EC, Tuthill MH. Hematopoietic stem cell transplantation. Stem Cells and Cloning Advances and Applications. 2010. doi:10.2147/sccaa.s6815.

BibTeX

@article{eleftheria2010Hemato, title = {Hematopoietic stem cell transplantation}, author = {Eleftheria ChR. Hatzimichael and Mark H. Tuthill}, journal = {Stem Cells and Cloning Advances and Applications}, year = {2010}, doi = {10.2147/sccaa.s6815}, }