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γH2AX as a molecular marker of aging and disease

Li-Jeen Mah, Assam El‐Osta, Tom C. Karagiannis

Epigenetics · 2010 · ▲ 154 citations

Epigenetic alterations Chronic inflammation Review

Abstract

Double-strand breaks are one of the most critical DNA lesions with respect to cell-death and preservation of genomic integrity. Rapid phosphorylation of the histone variant H2AX at Ser-139 to form gammaH2AX is an early cellular response to DNA double-strand breaks. Visualization of discrete gammaH2AX foci using immunofluorescence-based assays has provided a sensitive and effective method for detecting DSBs which may be implicated in various pathologies including cancer, age-related diseases, chronic inflammatory diseases and ischemia-reperfusion injury. In this review, the potential utility and significance of gammaH2AX as a molecular marker of aging and disease is analysed.

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Provenance

Source: OpenAlex
DOI: 10.4161/epi.5.2.11080
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Fetched: 2026-08-07 MST

Cite this

APA

Mah, L., El‐Osta, A., & Karagiannis, T.C. (2010). γH2AX as a molecular marker of aging and disease. <em>Epigenetics</em>. https://doi.org/10.4161/epi.5.2.11080

Vancouver

Mah L, El‐Osta A, Karagiannis TC. γH2AX as a molecular marker of aging and disease. Epigenetics. 2010. doi:10.4161/epi.5.2.11080.

BibTeX

@article{lijeen2010HAXasa, title = {γH2AX as a molecular marker of aging and disease}, author = {Li-Jeen Mah and Assam El‐Osta and Tom C. Karagiannis}, journal = {Epigenetics}, year = {2010}, doi = {10.4161/epi.5.2.11080}, }