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Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion

Miguel Ganuza, Cristina Sáiz-Ladera, Marta Cañamero, Gonzalo Goméz-López, Ralph P. Schneider, Marı́a A. Blasco, David G. Pisano, Jesús María Paramio, David Santamarı́a, Mariano Barbacid

The EMBO Journal · 2012 · ▲ 130 citations

Stem-cell exhaustion

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Abstract

A 2012 study in The EMBO Journal shows that genetic inactivation of Cdk7 causes cell cycle arrest and premature aging via adult stem cell exhaustion.

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Provenance

Source: OpenAlex
DOI: 10.1038/emboj.2012.94
Canonical: link ↗
Fetched: 2026-10-01 MST

Cite this

APA

Ganuza, M., Sáiz-Ladera, C., Cañamero, M., Goméz-López, G., Schneider, R.P., Blasco, M.A., Pisano, D.G., Paramio, J.M., Santamarı́a, D., & Barbacid, M. (2012). Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion. <em>The EMBO Journal</em>. https://doi.org/10.1038/emboj.2012.94

Vancouver

Ganuza M, Sáiz-Ladera C, Cañamero M, Goméz-López G, Schneider RP, Blasco MA, et al. Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion. The EMBO Journal. 2012. doi:10.1038/emboj.2012.94.

BibTeX

@article{miguel2012Geneti, title = {Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion}, author = {Miguel Ganuza and Cristina Sáiz-Ladera and Marta Cañamero and Gonzalo Goméz-López and Ralph P. Schneider and Marı́a A. Blasco and David G. Pisano and Jesús María Paramio and David Santamarı́a and Mariano Barbacid}, journal = {The EMBO Journal}, year = {2012}, doi = {10.1038/emboj.2012.94}, }