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G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders

Thian‐Sze Wong, Guangzhi Li, Shiliang Li, Wei Gao, Geng Chen, Shiyi Gan, Manzhan Zhang, Honglin Li, Song Wu, Yang Du

Signal Transduction and Targeted Therapy · 2023 · ▲ 149 citations

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Abstract

Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors. Identifying treatment targets is challenging because the diseases are resulting from heterogeneous biological, genetic, and environmental factors. Nevertheless, the increasing understanding of G protein-coupled receptor (GPCR) opens a new possibility in drug discovery. Harnessing our knowledge of molecular mechanisms and structural information of GPCRs will be advantageous for developing effective drugs. This review provides an overview of the role of GPCRs in various neurodegenerative and psychiatric diseases. Besides, we highlight the emerging opportunities of novel GPCR targets and address recent progress in GPCR drug development.

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Provenance

Source: OpenAlex
DOI: 10.1038/s41392-023-01427-2
Canonical: link ↗
Fetched: 2026-07-28 MST

Cite this

APA

Wong, T., Li, G., Li, S., Gao, W., Chen, G., Gan, S., Zhang, M., Li, H., Wu, S., & Du, Y. (2023). G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders. <em>Signal Transduction and Targeted Therapy</em>. https://doi.org/10.1038/s41392-023-01427-2

Vancouver

Wong T, Li G, Li S, Gao W, Chen G, Gan S, et al. G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders. Signal Transduction and Targeted Therapy. 2023. doi:10.1038/s41392-023-01427-2.

BibTeX

@article{thiansze2023Gprote, title = {G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders}, author = {Thian‐Sze Wong and Guangzhi Li and Shiliang Li and Wei Gao and Geng Chen and Shiyi Gan and Manzhan Zhang and Honglin Li and Song Wu and Yang Du}, journal = {Signal Transduction and Targeted Therapy}, year = {2023}, doi = {10.1038/s41392-023-01427-2}, }